Join Our Team.

We seek highly motivated professionals to join our team. We invite you to schedule a visit through Human Resources to learn more about our company and see our current open job postings below.

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Clinical

Working with CCXI Senior Management, Contract Development Organizations and selected Consultants, this individual is responsible for the development and overseeing the execution of all the technical activities associated with product development in support of Clinical Development and Commercialization. In particular those activities associated with analytical methods development in support of active pharmaceutical ingredient and drug product development.  The individual should be knowledgeable in drug product manufacturing process for oral solid dosage forms. In addition, this individual will be responsible for overseeing all the CMC activities supporting CCXI programs including the development timelines and deliverables according the Department goals.

Specific Responsibilities

  • The Pharmaceutical Development Senior Manager/Associate Director is responsible for providing project management and technical expertise to the CMC activities for ChemoCentryx programs.
  • Responsible for providing technical expertise to all the activities associated with the formulation and process development
  • Responsible for providing technical expertise with all the analytical development activities in support of API and DP development
  • Responsible for overseeing the manufacture of clinical trial materials at the selected CMO
  • Working closely with the QA organizations provide solid input in the resolution of issues associated with the manufacture and release fo CTM
  • Working closely with QA responsible for the development and maintenance of an accurate inventory of the Clinical Supplies
  • The scope of the responsibility is from IND, Phase 1, 2, 3 to Commercialization and post approval life cycle management.
  • The Senior Manager/Associate Director participates in all projects and will manage multiple program collaborating with the CCXI following groups: Process Chemistry, Biology, DMPK, Pre-
  • Clinical, Outsourcing, Clinical Operations, Quality, Finance and Regulatory Affairs.
  • The Senior Manager/Associate Director will have support project management to the Outsourced Key Accounts Teams.
  • Facilitates the design and implementation of initiatives with the CMO’s that improves business performance
  • Able to develop a strong background in performance metrics and reporting for business review meetings with the CMO’s
  • Follows up and drives the closure of action items from the team meetings and business review meetings
  • The Senior Manager/Associate Director should have significant knowledge, experience and skills with compliant Quality Management Systems in support of Product Development and overall CCXI business
  • Collaborating with CCXI Quality Organization, establishes, oversees, expands and maintains a SOP’s related to Pharmaceutical Development.
  • Leads continuous improvement efforts in quality systems and department infrastructure (including documentation) through the evaluation of current organizational process, audit feedback, and previous experience
  • Develops plans and implements actions to ensure readiness for regulatory and audit inspections.
  • Works closely with QA to support the review and approval of batch record, validation, specification and change control documentation produced by CMOs and CROs.
  • Working closely with PD management and QA oversees the CMOs and CROs performance associated with the investigations and effective closing of all deviations and ensures that robust corrective actions are identified and quickly implemented.
  • Establishes and maintains documentations specific for each CMO and each product related to outsourced operations (e.g. contractor manuals)
  • Performs CMC technical audits potential CMO’s to ensure technical capabilities, compliance to relevant regulations
  • Provides support for the oversight of site technical validation activities (analytical and drug product manufacturing).
  • Assists in the preparation and review of regulatory submissions for USA and worldwide heath agencies.

Requirements

  • BS, MS or PhD of a scientific degree with 5 to 15 years of technical and direct product development experience in the areas of Drug Product Formulation/Manufacturing Process/Analytical Development
  • Proven experience in the development of analytical methods and their qualification/validation in support to API and products in the late phases of development.
  • Deep knowledge of the GMP regulations requirements in product development manufacturing and release of clinical and commercial products
  • Knowledge of pharmaceutical packaging and labeling and current or impending regulations is desired but not essential
  • Proven track record in strategic planning for late stage development programs. Commercial experience desired.
  • Must have strong regulatory compliance knowledge including FDA, cGXP, etc.
  • Provide technical support during external audits of vendors and subcontractors
  • Must be detail oriented with excellent prioritization, organizational and project management skills.
  • Superior analytical and problem solving skills.
  • Effective communication (written and verbal) skills.
  • Ability to travel up to 30%

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Clinical Development/Medical Affairs

Job Description

This Medical Director level position requires the ability to work independently, with appropriate supervision, in responsibilities associated with all aspects of design, setup, monitoring, and analysis of Phase 1 – 3 clinical trials.  This person must have excellent analytical and communication skills, and the ability to interact effectively with other members of the department, as well as with study investigators and their staff, CROs and vendors operating on behalf of ChemoCentryx.  The individual also needs to be involved in other duties in the department including strategic planning, clinical plan development, potential partnering discussions, regulatory meetings, departmental meetings, planning and preparation for scientific meetings, staff training, and patient recruitment initiatives.

Responsibilities

  • Co-lead the C5aR (CCX168) and CCR2 (CCX140-B and CCX872-B) clinical development programs in renal diseases (often in orphan disease settings) and cancer; as such, participate in investigator outreach activities, design, placement, execution, data analysis, and report writing for the clinical trials, including Phase 1 through Phase 3 clinical trials.
  • Medical monitoring and regular safety review of active clinical trials.
  • Lead specific clinical trials, e.g., CCX168 Phase 1 and later stage clinical trials.
  • Attend scientific meetings on behalf of CCXI to meet with investigators and key opinion leaders, submit and present abstracts.
  • Organize and lead scientific advisory board meetings.
  • Be actively involved in planning and preparation of Regulatory meetings and submissions, e.g., CCX168 End-of-Phase 2 meeting.
  • Help mentor and guide other Department members.
  • Participation in generation and critical review of study-related documents including study protocols, protocol amendments, investigator brochures, monitoring plans, informed consent documents, and CRFs.
  • Includes travel up to 30% at times.

Desired Skills and Experience

  • Requires an MD with a minimum of 5 year of industry experience.
  • Experience in one or more of the following area(s):  Oncology, nephrology, and rheumatology desirable.
  • Prior training and experience with Good Clinical Practices (GCPs).
  • Excellent verbal and written skills along with the ability to work collaboratively in a dynamic and creative environment.
  • Ability to critically analyze and evaluate information/data and generate an appropriate action plan in a timely manner
  • Track record of creativity, high performance, and demonstrated ability to work independently and meet deadlines.
  • Ability to inspire and motivate others to achieve the corporate goalsExhibits initiative, is proactive and able to contribute to overall medical and clinical development activities.
  • This position requires attention to detail and the ability to interact effectively with other staff.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Research

Job Description

ChemoCentryx is seeking talented and highly motivated individuals with strong synthetic organic chemistry background to join our medicinal chemistry team. The successful candidate will apply skills in the design, synthesis and characterization of novel molecules, identify structure-property relationships in terms of potency, selectivity, pharmaceutic and pharmacokinetic properties, and use screening information to further optimize compounds. We expect the successful candidate to operate in a fast-paced multi-disciplinary team environment and also display the ability to independently solve complex medicinal chemistry challenges.

Responsibilities

  • Design, plan and execute the synthesis and purification of novel and complex small molecules
  • Propose novel structures based on emerging in vitro and in vivo biological, pharmacokinetic and pharmacology data
  • Exceptional interpersonal, verbal and written communication skills
  • Regularly provide project progress updates, identify challenges and communicate with a multidisciplinary team of scientists
  • Collaborate effectively with fellow team members to broadly overcome synthetic and medicinal chemistry project challenges
  • Adapt and adjust priorities as new data emerges to meet project goals
  • Contribute effectively to patent, report and scientific publication writing

Desired Skills and Experience

  • PhD or Master’s degree in chemistry with up to 3-7 years of industry experience
  • Strong background in synthetic organic chemistry and hands on experience with a wide range of techniques related to multi-step synthesis, purification, and spectroscopic identification
  • Proven track record of conceptual thinking, and translation to actual deliverables
  • Ability to independently solve complex problems relating to organic synthesis and medicinal chemistry
  • First-rate scientific expertise, knowledgeable with current synthetic and medicinal chemistry literature
  • Motivated team player who will be able to collaborate effectively in a multi-disciplinary team environment
  • Exceptional oral and written communication skills

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Job Description

We currently seek a Scientist to join our Biology Group. The position requires a Ph.D. in Immunology, Cancer Biology or related field, with strong history of publication in top tier scientific journals. The title is flexible and will be commensurate with the candidate’s background and experience.
ChemoCentryx is offering a unique opportunity for a highly motivated researcher to join our team focused on the discovering and developing orally-administered therapeutics to treat autoimmune diseases, inflammatory disorders and cancer.

Responsibilities

  • Provide foundational expertise in immune biology.
  • Evaluate and propose innovative immune oncology strategies and targets.
  • Make detailed observations, analyze data and interpret results.
  • Design and execution of experiments in animal models relating to autoimmune disorders and cancer.
  • Opportunities to Lead and mentor junior staff will be available.
  • Effectively represent the group in both internal and external presentations and publications.
  • Work collaboratively in a fasted-paced, entrepreneurial environment with project teams composed of Biology, Medicinal Chemistry, Pharmacology and Toxicology.
  • Provide internal and external presentations/publications to articulate research results, milestones, challenges, and plans.

Desired Skills and Experience

  • The successful candidates will have a PhD in Immunology, Cancer Biology or related field and have completed postdoctoral training.
  • Minimum of 4 years’ experience in the biopharmaceutical industry highly preferred.
  • Experience in cellular and molecular biology, immunohistochemistry and tissue culture desired.
  • Demonstrated track record of independent critical thinking and scientific achievement in the immunology and/or oncology.
  • Working knowledge in both in vitro and in vivo tumor biology is a plus.
  • Proficiency in designing and executing a variety of in vivo tumor model
  • Proven track record of publication in high impact scientific journals required.
  • Excellent verbal, written and problem solving skills are required.
  • Previous experience of working with human cells/tissues.
  • Demonstrated scientific productivity as evidenced by a strong record of publications, patents, and/or pipeline accomplishments.
  • Outstanding written, visual, and oral communication skills.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Administrative/Legal/Finance/Human Resources

Job Description

Administrative Assistant/Senior Administrative Assistant will provide administrative support to the Chief Financial Officer (CFO), Chief Medical Officer (CMO) and the Senior Vice President of Research.

Responsibilities

  • Set up meetings/activities via Outlook, draft/change/format documents using MS Word of MS Excel, prepare presentations using PowerPoint, answer calls, and file documents and process mail/correspondence.
  • Arrange and coordinate onsite and offsite executive meetings.
  • Make travel arrangements in accordance with preferences, prepare trip folders and prepare travel and expense reports for charges on corporate credit card.
  • Prepare, coordinate and distribute quarterly board committee packages. Provide assistance with preparation of board packages. Ensure directors’ travel arrangements are secured and coordinated. Maintain attendance records of board and committee meetings and assist the CFO in the scheduling of board and committee meetings and conference calls. Arrange catering and other requirements associated with board meetings.
  • Provide assistance in maintaining a complete and accurate corporate minute’s book. Ensure the timely execution by Secretary of approved board and committee minutes. Ensure minute’s book is up-to-date to include all minutes, consents and other written actions taken by the board, committees and stockholders. Assist the CFO in the coordination of the annual stockholders meeting.
  • Maintain files of all stock options grants and related activities. Ensure the timely distribution and return receipt of stock option agreements. Provide support to stock option administration, as appropriate.
  • Ensure files for all directors and officers are maintained and complete (e.g. Section 16 filings, D&O questionnaires, etc.).
  • Corporate phone support during the Receptionist’s lunch and rest breaks.
  • Perform special projects as requested.

Desired Skills and Experience

  • HS Diploma or equivalent 3 to 5 years of administrative support, preferably in biotechnology or technology.
  • Extremely professional with excellent written and verbal communication skills.
  • Attention to detail and follow through.
  • Time management, flexibility and organizational skills. Ability to multi-task and effectively prioritize in a dynamic and fast-paced environment.
  • Ability to work with confidential information in an appropriate manner and use discretion in communications.
  • Demonstrated team and collaborative work with other administrative staff.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

Submit Resume