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ChemoCentryx, a pharmaceutical company located in Mountain View, CA, seeks highly motivated professionals to join our team.

All ChemoCentryx employees share the rewards of their work through a generous stock option program. We also offer 401K and Flexible Spending Accounts, and a comprehensive benefits package, including medical, dental and vision coverage and life and long-term disability insurance.

Please email your resume & cover letter to: hiring@chemocentryx.com or FAX to: (650) 210-2910. No phone calls please. EOE


Associate Medical Director - Medical/Clinical Affairs

This Associate Medical Director level position requires the ability to work with supervision, in responsibilities associated with all aspects of design, setup, monitoring, and analysis of Phase 1 - 3 clinical trials. This person must have the ability to interact effectively with other members of the department, as well as with study investigators and their staff, CROs and vendors operating on behalf of ChemoCentryx. The individual is this position will also be required to be involved in other duties in the department including strategic planning, clinical plan development, potential partnering discussions, departmental meetings, planning and preparation for scientific meetings, staff training, and patient recruitment initiatives.

Responsibilities

  • Co-lead the CCX168 and CCX140-B clinical development programs in ANCA-associated glomerulonephritis and diabetic nephropathy, respectively; as such, participate in investigator outreach activities, design, placement, execution, data analysis, and report writing for the clinical trials, including Phase 1, Phase 2, and Phase 3 clinical trials.
  • Medical monitoring of active clinical trials in the CCR2, C5aR, and CCR9 antagonist programs.
  • Lead specific clinical trials, e.g., CCX168 Phase 1 and later stage clinical trials.
  • Attend scientific meetings on behalf of CCXI to meet with investigators and key opinion leaders, submit and present abstracts.
  • Organize and lead scientific advisory board meetings.
  • Be actively involved in planning and preparation of Regulatory meetings and submissions, e.g., CCX168 End-of-Phase 2 meeting.
  • Help mentor and guide other Department members.
  • Participation in generation and critical review of study-related documents including study protocols, protocol amendments, investigator brochures, monitoring plans, informed consent documents, and CRFs.
  • Includes travel up to 30% at times.

Education & Experience

Requires an MD with a minimum of 1 year of industry experience. Experience in one or more of the following area(s): Nephrology, rheumatology, internal medicine, or endocrinology desirable. Prior training and experience with Good Clinical Practices (GCPs). Excellent verbal and written skills along with the ability to work collaboratively in a dynamic and creative environment. Track record of creativity, high performance, and demonstrated ability to work independently and meet deadlines. Exhibits initiative, is proactive and able to contribute to overall medical and clinical development activities. This position requires attention to detail and the ability to interact effectively with other staff.

Reference Job Code: #012

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Director/Sr. Director - Pharmaceutical Development

This position requires the ability to work independently, in responsibilities associated with all aspects of chemistry, manufacturing and controls (CMC) for ChemoCentryx drug candidates. This person must have the ability to interact effectively with other members of the department, as well as with Regulatory agencies, consultants, and external vendors operating on behalf of ChemoCentryx. The individual is this position will also be required to be involved in other duties in the department including strategic planning, potential partnering discussions, departmental meetings, planning and preparation for consultant and Regulatory meetings, and staff training.

Responsibilities

  • Oversees and directs all chemistry, manufacturing and controls (CMC) regulatory and manufacturing strategies for new products.
  • Provides guidance and support to internal pharmaceutical development personnel as well as to outside groups such as contract manufacturing organizations to ensure that products are manufactured in compliance with all applicable regulations.
  • Provides strategic input and risk assessments and oversees preparation of CMC regulatory submissions.
  • Interacts with regulatory agencies.
  • Selects, develops and evaluates personnel to ensure the efficient operation of the function.
  • Directs the design and scale-up of processes, instruments and equipment from the laboratory through pilot plant and manufacturing scale-up.
  • Manages the development, implementation and maintenance of process methods and equipment for the production of process formulas, technologies and products to achieve cost effectiveness and product quality.
  • Plans and implements the development of new process formulas, establishes operating equipment specifications and may improve manufacturing techniques and new process equipment production.
  • Acts as liaison with research and/or development to ensure processes and designs are compatible.
  • Selects, develops and evaluates personnel to ensure the efficient operation of the function.

Education & Experience

Requires a PhD in a relevant field with a minimum of 5 years of industry experience. Prior training and experience with Good Manufacturing Practices (GMPs). Excellent verbal and written skills along with the ability to work collaboratively in a dynamic and creative environment. Track record of creativity, high performance, and demonstrated ability to work independently and meet deadlines. Exhibits initiative, is proactive and able to contribute to overall CMC activities. This position requires attention to detail and the ability to interact effectively with other staff. Level of position will be commensurate with level of experience.

Reference Job Code: #015

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Research Assistant/Associate - Biology (6 month temporary assignment)

As a member of the lead discovery and optimization group, your primary responsibility will be to develop high-quality antagonist that advance into preclinical development by providing high-quality biological data using a combination of in vitro biochemical and cell culture assays, including cell migration, radioligand binding and cytoplasmic calcium flux assays. Speed, quality and communication are essential skills for this position. In addition, handling and tracking novel compounds, growing mammalian cells in sterile tissue culture, handling laboratory robotics, maintaining accurate and complete records in a laboratory notebook, and being responsible for entering results into an Oracle database are required.

Basic requirements include a BS degree in biological sciences. Preferred qualifications include a MS and/or 1 to 2 years' experience in pharmacology or drug optimization.

Reference Job Code: #T001

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Scientist I - Biology

ChemoCentryx is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing orally-administered small molecule therapeutics that target the chemokine and chemo-attractant systems in order to treat autoimmune diseases, inflammatory disorders and cancer. We are building a strong pipeline that currently includes products in development for immunological diseases, metabolic disease and cancer. At ChemoCentryx, we are committed to developing innovative therapeutics, cutting-edge technologies and pursuing the highest quality science.

We are seeking a motivated professional to join our Biology Group and lead independent research efforts into the basic biological functions of the chemokine/chemo-attractant receptor system(s). The Scientist I will provide internal and external presentations/publications to articulate research results, milestones, challenges, and contribute to our drug discovery efforts. The successful candidate will enjoy working as a member of a fast-paced multidisciplinary team in an entrepreneurial environment.

Qualifications

  • PhD in Immunology, Cancer Biology, or related field and have completed postdoctoral training preferably in industry.
  • Experience with in vivo biological models preferred.
  • Experience in a drug discovery environment preferred.
  • Experience in multi-color flow cytometry necessary.
  • Strong molecular biology experience is a plus.
  • Experience in immunohistochemistry and tissue culture is desired.
  • Previous experience of working with human cells/tissues is a plus.
  • Excellent verbal, written and problem solving skills.
  • Proven track record of publication in high impact scientific journals.

Reference Job Code: CCX#14

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