EnabaLink^® Drug Discovery Engine

To better understand the chemokine system and to accelerate the identification of small molecule leads, we have developed a suite of proprietary technologies, known as the EnabaLink^® drug discovery engine. This platform provides us with a one-of-a-kind advantage in the rapid identification of highly specific product candidates and includes the following tools developed by the company:

• Comprehensive Map of the Chemokine Network

We have developed the first comprehensive functional genomic map of the chemokine system which furnishes us with a thorough understanding how a given chemokine-chemokine receptor interaction impacts the migration of cells in a given disease.

• Reverse Activation of Migration (RAM) Assays and Screening Technology

ChemoCentryx has also developed a purpose-built high-throughput robotic screening technology, known as the Reverse Activation of Migration, or RAM, Assay, to identify small molecule antagonists for the chemokine receptor most closely associated with a specific disease. The RAM Assay is designed to markedly reduce or eliminate non-specific inhibitors and toxic inhibitors of cell migration, resulting in highly specific lead candidates. This technology allows ChemoCentryx to screen against otherwise intractable targets, providing it with a unique competitive advantage in drug discovery.

ChemoCentryx has leveraged its EnabaLink drug discovery engine for the identification and optimization of each of its clinical and pre-clinical product candidates. We continue to apply these powerful research tools in our early-stage drug discovery efforts.