Join Our Team.

We seek highly motivated professionals to join our team. We invite you to schedule a visit through Human Resources to learn more about our company and see our current open job postings below.

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DMPK

Description:

Primary responsibilities include all aspects of preclinical development including the design, execution, management and regulatory submissions of all non-clinical safety studies during the course of preclinical development and clinical development of the company’s drug development programs. You will:

  • Plan and design all nonclinical studies, including non-GLP and GLP studies (safety pharmacology and toxicology studies), primarily through contract research organizations (CROs);
  • Manage the budget for non-clinical safety studies;
  • Manage contracts and coordinate activities with CROs; Serve as study monitor;
  • Prepare study reports and regulatory documents, including investigator’s brochures, INDs and NDAs;
  • Contribute to and participate in meetings and interactions with regulatory agencies;
  • Work closely with other functional areas such as Biology, Medicinal Chemistry, DMPK, CMC and Clinical;
  • Provide strategic preclinical expertise to cross-functional project teams as the in-house preclinical expert.

Qualifications / Experience:

  • Demonstrated expertise in nonclinical study design and management with small molecule drug candidates;
  • Demonstrated track record of successful regulatory filings;
  • Adequate understanding and experience in PK/TK studies;
  • Experience in contracting and managing safety studies with reputable CROs;
  • Ph.D. in toxicology, pharmacology, physiology, biology, or related discipline. DABT preferred but not required;
  • Minimum of 10 years of preclinical safety experience in the pharmaceutical/biotechnology industry experience;
  • Experience with pre-IND through Phase 1-3 programs and associated regulatory filings;
  • Experience in working with U.S. and European regulatory authorities;
  • Highly motivated; well organized; multi-tasking;
  • Strong critical thinking and analytical skills;
  • Excellent communication and presentation skills;
  • Excellent team management skills

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Description:

The primary responsibility of the position is to design and conduct in vitro ADME assays (e.g., CYP inhibition, metabolic stability and protein binding) and perform in vivo pharmacokinetic sample bioanalysis to support drug discovery and development. The incumbent will work closely with project teams to perform investigative DMPK studies to guide optimization of ADME properties and selection of potential drug candidates.

Qualifications and Experience:

  • BS, MS or PhD degree in biochemistry, analytical or organic chemistry, or other relevant fields
  • For candidates with a BS or MS degree, a minimum of 3 years of experience with in vitro DMPK assays in the drug discovery or drug development environment; for candidates with a PhD, no industry experience is required
  • Hands-on experience with in vitro ADME assays including CYP inhibition, metabolic stability and protein binding is required; experience with metabolite identification is desired
  • Hands-on experience with LC/MS/MS (e.g., Sciex triple quadrupole or Thermo Q-Exactive) is required
  • Ability to troubleshoot and optimize assays as needed
  • Excellent communication skills (especially written) are required

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Finance

ChemoCentryx, Inc. is seeking an Assistant Controller to manage our day to day accounting activities. Located in Mountain View the position will manage multiple accounting functions, including payroll, equity, stock-based compensation, accounts payable and general accounting. The position will report to the Vice President, Finance but will be the primary driver for day to day activities.

The ideal candidate will have at least 10 years of combined experience in a leadership role at a public company and/or public accounting firms. This position reports directly to the VP, Finance/Controller.

Principal Duties And Responsibilities:

  • Under the direction of the VP, Finance, responsible for leading the corporate accounting function with emphasis on maintaining effective internal controls and documentation.
  • Manage multiple aspects of accounting – financial statements, general ledger, payroll, equity, stock-based compensation, accounts payable, accounts receivable, and various special analyses.
  • Ensure all balance sheet reconciliations are prepared each month and are accurate and comply with documentation requirements.
  • Review monthly accounting close process including analytical review of the monthly operating results to ensure accurate accounting records are maintained.
  • Sustain Company’s Sarbanes-Oxley Section 404 compliance efforts with respect to payroll, equity, stock-based compensation, accounts payable, debt and related monthly close and other activities.
  • Assist with the review of quarterly reports (Form 10-Q) and annual reports (Form 10-K).
  • Perform special projects and other analytical support as requested.
  • Manage a team of three staff members.

Job Scope

Works with all employees to assist in financial accounting matters.

Interaction  (level of positions, nature of interaction, frequency):

Internal Contacts: Regularly interacts with company leaders and other employees regarding finance and accounting related matters.

External Contacts: Regularly interacts with external auditors (government and corporate) and vendors.

Amount of Supervision Received:  Requires minimal-to-moderate level of supervision.  Minimum supervision on routine matters, moderate supervision on more complex matters.

Specifications

Education:  BA/BS in Accounting/Finance.

Experience:

  • Minimum of ten (10) years of relevant accounting experience, including Big 4 Public Accounting experience.
  • CPA license required.
  • Experience in public biotechnology or biopharmaceutical company experience preferred.
  • Prior experience in a SOX oversight role preferred

Skills and Capabilities :  (Specific abilities needed for the position)

  • Energetic, flexible team player and hands-on leader with the ability to manage in a dynamic environment. Diplomatic yet effective in garnering respect and cooperation from management of other function areas.
  • Process and system orientation with an understanding of internal controls.
  • Strong attention to details and accuracy.
  • Excellent written and oral communication skills, including ability to communicate effectively with external parties and all levels of staff in a timely fashion.
  • Results orientation with an ability to manage the overall project and meet deadlines.
  • Flexible and able to adapt to growing organizations and deal with the Company’s changing needs and priorities.
  • Proficiency with MS Excel, Word and Great Plains
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Marketing

Summary/Objective:

This role is responsible for the management and execution of strategies and tactical programs to effectively achieve development, commercialization, and life cycle planning objectives for Avacopan. The senior director is responsible for the management of the Avacopan marketing team, including brand vision, short and long term strategic planning and tactical execution to maximize revenue growth within budget.

Specific Responsibilities:

  • Develops a unified strategic vision for avacopan professional and patient promotions
  • Ensures development of strategic and tactical plans for avacopan professional and patient promotions to deliver on brand plan goals
  • Directs and controls the activities of the avacopan marketing team. Accountable for leading, hiring and developing talent.
  • Responsible for major agency partners, including alignment to strategic imperatives for growth
  • Determines marketing needs for avacopan by actively monitoring markets through primary and secondary market research, US congress participation, and US opinion leader interactions
  • Cultivates and maintains relationships with key opinion leaders in the various professional scientific businesses and customer communities; participates in advisory board meetings with key opinion leaders
  • Manages the development and management of an operating budget that reflects the nature of the marketing plan
  • Evaluates on a continuous basis the efficacy of communications/sales by targeted audiences by business segments
  • Partners with colleagues cross-functionally throughout organization in US and globally to ensure alignment and effective execution of key avacopan priorities

Requirements:

  • Undergraduate degree in marketing or sciences with 15 years relevant experience of which ten years are in marketing and product management; equivalent combination of advance degree and experience may be considered.
  • MBA or other advanced degree
  • Experience in product launch strongly preferred
  • Experience in pharmaceutical sales strongly preferred
  • Experience managing teams
  • Proven success working in complex specialty markets – preferably nephrology and/or rheumatology
  • Excellent organizational, analytical, problem-solving, and communication skills
  • Able to manage marketing functions of one or more functional areas, divisions, product groups, or service groups through managers with overall responsibility for direction of those assigned areas
  • Practical, yet visionary and self-motivated; action-oriented and possess strong leadership and prioritization skills
  • Background and persona to inspire and lead others both inside and outside of the ChemoCentryx, at the same time gaining respect

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Medical Affairs

Summary:

Reporting to the VP – Medical Affairs, this position will support the Medical and Scientific Communications platform, including Medical Education, Publications and Congress Strategy at ChemoCentryx. Through cross-functional collaboration, you will oversee the development and execution of the scientific platform and medical narrative of company products, as well as contribute to medical information, product dossiers and scientific communications plans (manuscripts and abstracts) as the organization grows and prepares for its first product launch. You will manage external vendors, including medical writing and medical information agencies as well as internal resources in the development of custom and standard response letters, congress booths content for Medical Affairs, abstracts, posters and manuscripts. You may assist in the planning of advisory boards and also review process of continuing medical education (CME) grant requests, as needed.

Essential Job Functions:

  • Manages and maintains a strategic medical communication and publications plan.
  • Contributes to the publication planning and execution according to established guidelines (e.g., GPP3, ICMJE).
  • Contributes to Medical Affairs Congress planning activities, such as medical education and medical affairs booth content, as needed.
  • Identifies and makes recommendations on opportunities for Medical Education
  • Along with the Medical Director, interfaces with commercial and clinical groups as key contributor to the Competitive Intelligence activities in therapeutic areas of relevance to assigned portfolio agents.
  • Oversees external vendor operations that support Medical Affairs communication activities, including first line response to inquiries and requests for medical information.
  • Contributes to the development of slide decks and other presentation materials, as needed

Qualifications and Experience:

  • RN, PharmD, PhD or MD
  • Industry experience with a minimum of 5 years in a similar role or specific medical writing and editing experience, including relevant experience working in a medical information and/or communication group.
  • Prior experience working in rare diseases a plus
  • Advanced knowledge and understanding of rules and regulations impacting medical communications practices in the US
  • Collaborative, with excellent interpersonal skills
  • Prior experience working with Medical Directors on the development of strategic communication imperatives a plus
  • Demonstrated ability to manage several projects simultaneously
  • Must demonstrate a high level of proficiency with Microsoft Word, Excel and PowerPoint
  • May require travel up to 20-30% of the time to attend Conferences and meetings for publication planning or execution purposes.
  • Title and scope of responsibilities commensurate with experience.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Pharmaceutical Development

Summary/Objective:

Working within internal functional partners, external contract development organizations and selected consultants, this individual is responsible for the development and overseeing the execution of technical activities associated with late stage product development and manufacturing in support of clinical development, regulatory filings and product commercialization.

Key individual and leader of the team responsible for manufacturing, packaging and release of commercial products by the Contract Manufacturing Organizations. Additionally, this individual will support the manufacturing and release of the Drug Substance and Regulatory Starting Materials by the CMO’s.

Specific Responsibilities:

  • Oversees program plan development, tracks and updates milestones and key activities
  • Working with PD management and other internal partners, establish and track progress in the execution of the technical drug product strategies in support of NDA/MAA filings, product approvals and commercialization
  • Responsible for providing project management and technical expertise to late phase CMC activities, in particular with those activities associated with drug product manufacturing, packaging and release.
  • Responsible for providing technical expertise to all the GMP activities associated with the outsourcing the development and manufacturing of drug substance, starting materials, analytical development formulation and manufacturing process for product in late development and during commercialization.
  • Responsible for overseeing the manufacture of clinical trial materials at the selected CMO
  • Responsible for overseeing the manufacturing packaging and release of commercial products
  • Working closely with the QA organizations provide solid input in the resolution of issues associated with the manufacture and release of clinical supplies and commercial products
  • Working closely with QA responsible for the development and maintenance of an accurate inventory of the Clinical Supplies and commercial product
  • The scope of the responsibility is from IND, Phase 1, 2, 3 to NDA filing and approval and during the commercialization of CCXI products.
  • The Associate Director participates in all projects and manages multiple program collaborating with the CCXI following groups: Process Chemistry, Biology, DMPK, Pre-Clinical, Outsourcing, Clinical Operations, Quality, Finance and Regulatory Affairs.
  • The Associate Director will support project management in all technical activities associated with all development programs and product in commercialization
  • Facilitates the design and implementation of initiatives with the CMO’s that improves business performance
  • Able to develop a strong background in performance metrics and reporting for business review meetings with the CMO’s
  • Follows up and drives the closure of action items from the team meetings and business review meetings
  • The Associate Director should have significant knowledge, experience and skills with compliant Quality Management Systems in support of Product Development and overall CCXI business
  • Collaborating with CCXI Quality Organization, establishes, oversees, expand and maintains a SOP’s related to Pharmaceutical Development.
  • Leads continuous improvement efforts in quality systems and department infrastructure (including documentation) through the evaluation of current organizational process, audit feedback, and previous experience
  • Develops plans and implements actions to ensure readiness for regulatory and audit inspections.
  • Works closely with QA to support the review and approval of batch record, validation, specification and change control documentation produced by CMOs and CROs.
  • Working closely with PD management and QA oversees the CMOs and CROs performance associated with the investigations and effective closing of all deviations and ensures that robust corrective actions are identified and quickly implemented.
  • Establishes and maintains documentations specific for each CMO and each product related to outsourced operations (e.g. contractor manuals)
  • Performs CMC technical audits potential CMO’s to ensure technical capabilities, compliance to relevant regulations
  • Provides support for the oversight of site technical validation activities (analytical, manufacturing, etc).
  • Assists in the preparation and review of regulatory submissions for USA and worldwide heath agencies.
  • Provide technical support during external audits of vendors and subcontractors
  • Principal author of Contract Manuals

Requirements:

  • BS, MS or PhD scientific degree with a minimum of 10 years of technical and direct product development experience for late stage Product Development and during product commercialization
  • Candidate should be considered an expert in late stage small molecules product development with proven technical experience in one or more of the following areas: Process Chemistry and manufacturing scale-up for drug substance, analytical method development for drug substance and drug product formulation and manufacturing process for Phase III and commercial drug product.
  • Proven experience as it relates to managing and interaction with CMO’s from early through late drug product development
  • Program Management skills highly desired.
  • Experience in authoring CTD sections as they relate to drug substance, drug product, analytical chemistry and specification settings in support of IND’s, NDA’s, MAA’s and IMPD’s
  • Deep knowledge of the GMP regulations requirements in product development manufacturing and release of clinical and commercial products
  • Proven track record in strategic planning for late stage development programs. Commercial experience highly desired.
  • Must have strong regulatory compliance working knowledge including FDA, cGXP, etc.
  • Must be detail oriented with excellent prioritization, organizational and project management skills.
  • Superior analytical and problem solving skills.
  • Effective communication (written and verbal) skills.
  • Ability to travel up to 30%

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Summary/Objective:

Working with internal functional partners , external contract development organizations and selected consultants, this individual is responsible for the development and overseeing the execution of all the analytical chemistry  activities corresponding to analytical development, analytical method development, validation and their implementation in support of late stage product development, manufacturing and commercialization of all ChemoCentryx products.

The Associate Director function is key in the supply chain in support of the manufacture and release of regulatory starting materials, drug substance and final drug product.

Specific Responsibilities:

  • Working with PD management and other ChemoCentryx partners, establish and track progress in the execution of the technical strategies regarding implementation of analytical methodologies, tracking and reporting on all stability programs in support of NDA/MAA filings and product approvals
  • Responsible for providing project management and technical expertise as they relate to analytical chemistry for CMC activities for all ChemoCentryx commercial and clinical products.
  • Principal contributor in the establishment of specifications for raw materials, drug substance and final drug product. Main contributor in the establishment of rational analytical methods for in-process controls for the manufacturing of raw materials, drug substance and drug product in accordance to regulatory and quality commitments.
  • Responsible for providing technical expertise to all the GMP activities associated with the outsourcing the development and manufacturing of drug substance, starting materials, analytical development for products in late development and during commercialization.
  • Responsible for providing technical expertise and overseeing all the analytical activities executed by CMO’s including those in support to production and release of raw materials, drug substance and final drug product.
  • Working closely with PD Management and the respective QA organizations provide solid input in the resolution of deviations associated with the manufacture and release of commercial and clinical drug products
  • The scope of the position responsibility is from Phase 3 thru commercialization and post approval life cycle management.
  • The Associate Director manages multiple programs collaborating with the CCXI following groups: Process Chemistry, Biology, DMPK, Pre-Clinical, Outsourcing, Clinical Operations, Quality, Finance and Regulatory Affairs.
  • Facilitates the design and implementation of initiatives with the CMO’s that improves business performance
  • Able to develop a strong background in performance metrics and reporting for business review meetings with the CMO’s
  • Follows up and drives the closure of action items from the team meetings and business review meetings
  • The Associate Director should have significant knowledge, experience and skills with compliant Quality Management Systems in support of Product Development, Product Commercialization and overall CCXI business
  • Collaborating with CCXI Quality Organization, establishes, oversees, expand and maintains a SOP’s related to Pharmaceutical Development and Technical Operations.
  • Leads continuous improvement efforts in quality systems and department infrastructure (including documentation) through the evaluation of current organizational process, audit feedback, and previous experience
  • Develops plans and implements actions to ensure readiness for regulatory and audit inspections.
  • Works closely with QA to support the review and approval of batch record, validation, specification and change control documentation produced by CMOs and CROs.
  • Working closely with PD management and QA oversees the CMOs and CROs performance associated with the investigations and effective closing of all deviations and ensures that robust corrective actions are identified and quickly implemented.
  • Establishes and maintains documentations specific for each CMO and each product related to outsourced operations (e.g. contractor manuals)
  • Performs CMC technical audits potential CMO’s to ensure technical capabilities, compliance to relevant regulations
  • Responsible for the development and implementation of strategies in support of the Chemistry Manufacturing and Controls (CMC) sections of all CCXI regulatory submissions
  • Principal author of the CMC sections of global regulatory submissions
  • Provides technical support during internal and external audits of vendors and subcontractors
  • The candidate is expected to, in coordination with the CMO’s, to maintain the different stability and reference standards programs  for drug substance, raw materials and drug product

Requirements:

  • BS, MS or PhD scientific degree with a minimum of 10 years of technical and product development experience for late stage pharmaceutical products and /or as a member of the Technical Operations team supporting commercialization of products
  • Candidate is considered an expert in late stage small molecules product development with proven technical experience in the following areas: analytical method development, validation and implementation in support of drug substance, raw materials and drug product.
  • Proven experience as it relates to managing and interaction with CMO’s from early through late drug product development
  • Program Management skills highly desired.
  • Experience in authoring CTD sections  as they relate to drug substance, drug product, analytical chemistry and specification settings
  • Deep knowledge of the GMP regulations requirements in product development manufacturing and release of clinical and commercial products
  • Proven track record in strategic planning for late stage development programs. Commercial experience highly desired.
  • Must have strong regulatory compliance working knowledge including FDA, cGXP, etc.
  • Must be detail oriented with excellent prioritization, organizational and project management skills.
  • Superior analytical and problem solving skills.
  • Effective communication (written and verbal) skills.
  • Ability to travel up to 30%

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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Regulatory

Summary/Objective
The Director will serve as the global regulatory leader for defining and implementing the Regulatory strategy for the development of ChemoCentryx’s lead product candidate.

He/She will lead, grow and oversee all global regulatory interactions and filings. Provide regulatory leadership to cross-functional teams responsible for global programs ensuring effective communication with business partners and representatives of the US Food and Drug Administration and other Health Authorities worldwide. In addition, the position will assist corporate senior management in understanding Regulatory strategies/processes while developing corporate objectives and understanding the impact of decisions.

Essential Duties & Responsibilities:
Essential functions and responsibilities include the following:

  • Provide regulatory strategic and tactical leadership for drug development projects, including health authority interactions, regulatory submissions and other regulatory requirements in line with corporate objectives, timelines and budgets
  • Establish and develop regulatory policies, procedures and best practices commensurate with the requirements of a rapidly growing company
  • Serve as liaison with FDA and other Health Authorities, including leading meetings and preparations to facilitate expedited approval of original applications and supplements
  • Contribute hands on support, when needed, in managing, planning, coordinating, and preparing all documents submitted to FDA and other Health Authorities in support of INDs, MAAs, CTAs, amendments, safety reports, and annual updates
  • Ensure completeness and accuracy of information provided in regulatory submissions.
  • Continually monitor newly published FDA guidelines and international guidance documents in the context of new and ongoing development programs
  • Oversee preparation of regulatory presentations for internal governance meetings

Qualifications:

  • BS Required. Advanced degree is preferred (MS/PhD/PharmD)
  • 10+ years industry experience in regulatory affairs in bio/pharma industry
  • Strong knowledge of FDA regulations and EU CTA requirements
  • Delivery of a number of major applications (NDNBLA/MAA/JNDA etc.) and lead role preferred.
  • Comfortable with setting strategies aswell’as taking a hands-on approach to all regulatory activities
  • Experience with preparing regulatory documents including new INDs, safety reports, Investigator
    Brochures, DSURs, PSURs, briefing packages and other regulatory submissions required
  • Experience interacting/negotiating with regulatory authorities (e.g. FDA, EMA, etc.)
  • Strong leadership and communication skills and experience in working with multiple functional areas
  • Prior experience in the immunology therapeutic area would be helpful
  • Solid knowledge and understanding of complex medical and scientific subject matter as well as evolving regulatory policy and guidance
  • Ability to motivate and lead others
  • Team player, ability to thrive in a collaborative and fast-paced environment and work well within cross-functional teams
  • Excellent oral communication and writing skills

We participate in E-Verify, the US Government sponsored right-to-work verification process.

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A leading, autoimmune focused biotechnology company is looking for an Associate/Coordinator, Regulatory Affairs to join their growing regulatory team. This is an exciting, growth opportunity to support the development and implementation of global regulatory strategies encompassing clinical, non-clinical and CMC.

Key Responsibilities

  • Participates in the preparation of documentation packages for regulatory submissions (including IND, CTA, NDA, etc.) to the FDA and other regulatory agencies.
  • Formats, edits, coordinates and reviews regulatory documentation for inclusion in INDs, CTAs, and other worldwide submissions.
  • Compiles documentation for submissions to FDA and foreign regulatory agencies.
  • Maintains regulatory documentation including submissions to and correspondence with each governing authority.
  • Reviews clinical and technical documentation for typographical errors/ regulatory compliance.
  • Performs other appropriate administrative duties, such as preparing correspondence (records of contact), filing, quality management system support, meeting coordination and taking minutes.
  • Maintains chronological and operational trackers.
  • Responsible for maintenance of regulatory affairs files

Educational Requirements

  • B.A. or B.S. degree in an appropriate scientific field
  • If adequate Regulatory Affairs experience, could consider Associate degree

Experience and Skill Requirement:

  • Two plus years’ experience in a Regulatory Affairs/Regulatory Operations capacity is preferred.
  • Knowledge and practical understanding of ICH Guidelines regarding GMP/GCP, ICH Guidelines for CTD/eCTD and CDER requirements for the drug approval process.
  • Previous participation in preparing regulatory submissions (IND, CTA, BLA, etc.) to the FDA and EU Regulatory Authorities.
  • Solid understanding of the e-CTD specifications for electronic submissions
  • Previous experience in documentation preparation/publishing using Adobe Acrobat.
  • MS Office Expertise: Outlook, Word, Excel, PowerPoint
  • Strong interpersonal, organizational, and time management skills.
  • Ability to handle matters of strict confidentiality and sensitivity.
  • Strong attention to detail, organized, and dependable.

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process.  www.dhs.gov/E-Verify.
To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees. 
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Research

We are looking for a highly talented and exceptional leader in medicinal chemistry to join our small molecule drug discovery team.  The successful candidate will play a key role in advancing our diverse drug discovery programs.

Job Responsibilities:

  • As a member of the chemistry leadership team, lead a strong group of medicinal chemists working on multiple lead optimization programs
  • Direct efforts for the design and implement strategies for the synthesis of novel molecules in diverse optimization efforts and advance targets to candidate selection
  • Work closely with the biology group and proactively evaluate new biological targets and start new programs
  • Effectively lead and manage the productivity of cross-functional small molecule drug discovery teams to advance aggressive corporate goals
  • Provide regular assessment of project status to multidisciplinary scientific team and senior management
  • Lead by example and contribute to the writing of patents applications, reports, and scientific publications

Qualifications:

  • PhD in synthetic organic chemistry with a minimum of 10 years of medicinal chemistry experience in biotech/pharmaceutical industry
  • Proven ability to provide mentorship to both highly experienced staff and new hires
  • Knowledgeable and experienced in the broad area of small molecule drug discovery with insightful understanding of emerging industry trends
  • Demonstrated success in leading small molecule drug discovery programs from project inception through lead optimization, preclinical evaluation to development candidate nomination
  • Enthusiastic and high energy leader with outstanding scientific expertise, conceptual thinking, problem solving skills; ability to motivate teams to expeditiously change course as required in a fast-paced organization
  • Proven track record of partnering with multi-disciplinary team setting through expertise in Chemistry, Biology, DMPK, Pharmacology and Toxicology and others
  • Must have excellent oral and written communication skills

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process.  www.dhs.gov/E-Verify.
To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees. 
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Summary
We are seeking a highly motivated Research Associate to perform animal work involved with the husbandry and technical procedures of laboratory rodents. Responsibilities include conducting pharmacokinetic studies and various pre-clinical pharmacology models, particularly models of immunology and cancer.

The candidate will report to the Senior Scientist, Manager of Vivarium Science. We expect the successful candidate to thrive in a dynamic environment, working on accelerated timelines, and enjoy creative and challenging work within a multidisciplinary team.

Essential Duties and Responsibilities:

  • Performing and recording daily clinical observations for multiple animal models.
  • Update and maintain study logs accurately and in a timely manner.
  • Conduct pharmakonetic and toxicology studies in support of efficacy studies.
  • Technical proficiency in animal dosing by various routes (IV, IP, SC, PO).
  • Performing routine procedures such as weighing, blood collection and scoring of efficacy models.
  • Assist in performing small animal surgery.
  • Must be available for weekend and holiday rotations for dosing and monitoring of studies.
  • Performing other related duties as required.
  • Excellent oral and written communication skills
  • Self-motivated and highly organized
  • Ability to interact professionally with all employees and outside personnel.
  • Able to work independently as well effectively and harmoniously as part of a team in a fast-paced research environment
  • Proficiency with computers and standard application software.

Education:

  • High school or GED required.
  • Bachelor’s degree in science preferred. Practical knowledge of IACUC policies desired.

Experience:
Minimum of 2 years of experience conducting and dosing of animal studies.

Contract:
6 months

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process. www.dhs.gov/E-Verify.

To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

Submit Resume

ChemoCentryx is seeking highly talented and motivated scientists with a strong synthetic organic chemistry background to join our medicinal chemistry team. The successful candidates will contribute to our expanding pipeline of promising therapeutics and will have an outstanding opportunity for professional growth. We expect the successful candidates to operate in a fast-paced, multi-disciplinary team environment and to independently and collaboratively solve complex synthetic and medicinal chemistry challenges.

Job Responsibilities:

  • Apply organic and medicinal chemistry skills in the design and rapid synthesis of novel small molecules as potential drug candidates
  • Closely follow emerging results of biological testing, ADME characterization, and other lead profiling assays; proactively propose new strategies and new target molecules to improve key drug attributes
  • Maintain a high level of productivity in the laboratory through diligence and appropriate planning
  • Regularly summarize results and provide progress updates to the chemistry and cross-functional project teams
  • Contribute to the writing of patent applications, study reports, and scientific publications
  • Positions offer potential for management of direct reports

Qualifications:

  • PhD in organic chemistry; or MS with 3 or more years of medicinal chemistry experience in pharmaceutical industry
  • Strong background in organic synthesis and experience with a wide range of techniques related to multi-step synthesis, purification, and spectroscopic analysis
  • Proven track record of achievements through conceptual thinking and translation to results, as demonstrated by publications and patent applications
  • Ability to independently identify and address complex problems in synthetic chemistry
  • Self-motivated and enthusiastic; fast learner who can identify the core project challenges and expeditiously change course as required in a fast-paced organization
  • Team player who will be able to collaborate effectively in a multi-disciplinary team environment
  • Exceptional oral communication and writing skills

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process.  www.dhs.gov/E-Verify.
To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees. 
Submit Resume

ChemoCentryx is seeking a highly talented and motivated scientist to join our small molecule drug discovery team.  The successful candidate with a deep passion for drug discovery and a track record of accomplishments will play a key role in building our expanding pipeline of promising therapeutics.

Job Responsibilities:

  • As a lead scientist, establish project goals/scientific strategies and effectively drive the medicinal chemistry efforts to meet aggressive corporate timeline
  • Closely follow emerging results of biological testing, ADME characterization, and other lead profiling assays; conceive and execute new scientific strategies for the rapid optimization and improvement of key drug attributes
  • Proactively gain competitive intelligence using available resources and incorporate this knowledge into internal drug discovery programs
  • Regularly provide medicinal chemistry and project updates to a multidisciplinary drug discovery team and senior management
  • Maintain a high level of productivity in the laboratory as evidenced by consistently generating high-impact compounds
  • Lead and contribute to the writing of patent applications, study reports, and scientific publications
  • Position may involve management of direct reports, depending on level of experience

Qualifications:

  • PhD in organic chemistry or equivalent with at least 3 years of medicinal chemistry experience in pharmaceutical industry
  • Extensive knowledge of synthetic organic chemistry and superior problem solving skills; experience in designing and executing multistep synthesis of complex organic molecules using modern techniques in organic chemistry
  • Solid understanding and application of pharmacology, PK/PD, and ADME concepts
  • Ability to independently identify and promptly resolve core project challenges by effectively utilizing available information and scientific expertise
  • Demonstrated success in lead optimization, structure-activity relationship analysis, and property-oriented drug design, leading to development candidate nomination
  • Enthusiastic, high energy, and collaborative team player with strong ability to build productive relationships with scientists in the chemistry department and other disciplines to enable high individual performance and team success
  • Exceptional oral communication and writing skills
  • Previous supervisory and project leading experience highly preferred

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process.  www.dhs.gov/E-Verify.
To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees. 
Submit Resume

Summary/Objective
We are currently seeking Senior Research Associate to join our Biology Group. The position requires a M.S. or Ph.D degree in Biological sciences, preferably with experience in immunology, cancer biology, neuroscience or related area. The primary responsibilities will be focused on conducting studies examining the activity and mechanism of action of immune-modulatory compounds in in vitro assay systems and also support animal model studies.

Responsibilities:

  • Plan and conduct various experiments that include but are not limited to:
  • Cell culture and cell-based assays with both cell lines and primary cells, collection and processing of animal tissue, Flow cytometry (FACS), ELISA, Immunohistochemistry, immunofluorescence, and other basic biochemical/molecular biology assays.
  • Document all scientific work in lab notebooks and follow established standard operating procedures on data documentation and notebooks.
  • Analyze experimental data, prepare and submit detailed technical reports, and present results at team meetings.
  • Work as a member of an integrated team in a highly collaborative environment.

Qualifications:

  • M.S. or Ph.D in Cell Biology, Biochemistry or a related discipline.
  • At least 3 years of hands-on laboratory research experience post graduate, preferably in immunology/cancer biology/neuroscience research area. Experience in industry is a plus
  • Previous experience in multi-color flow cytometry, cell culture, and various immunological assays, biochemical/molecular biology assay, and in vivo disease model studies.
  • Capable of planing critical experiments, making detailed observations, analyzing data and interpreting results. Excellent record-keeping and organizational skills a must.
  • Capable of working both independently and in a collaborative team setting.
  • Excellent verbal, written communication and problem solving skills.

Contract Terms:
6 months

As an equal opportunity employer, ChemoCentryx, Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. For more information about equal employment opportunity protections, please view the ‘EEO is the Law’ poster.

In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@chemocentryx.com for assistance.

ChemoCentryx, Inc. is enrolled in E-Verify® and participates in E-Verify® in addition to our Form I-9 process. www.dhs.gov/E-Verify.

To all recruitment agencies: ChemoCentryx, Inc. does not accept unsolicited agency resumes and will not be responsible for the payment of placement fees related to unsolicited resumes submitted to open positions, job aliases, or to our employees.

We participate in E-Verify, the US Government sponsored right-to-work verification process.

Submit Resume